The Thursday opening will be a soft opening for the hotel. A grand opening celebration will be held in June.
The independent, boutique hotel is located in the former Pabst Brew House and Mill House buildings, located northwest of Juneau Avenue and North 10th Street.
The hotel is one of several new hotels coming to downtown Milwaukee. A Hilton Garden Inn opened last year in the historic Loyalty Building southwest of Broadway and Michigan Street. A 205-room Marriott hotel will open later this year. A 382-room hotel will open next year next to Potawatomi Bingo Casino, which is located near downtown in the Menomonee Valley.